Screening for Learning and Memory Mutations: A New Approach.
نویسندگان
چکیده
We describe a fully automated, live-in 24/7 test environment, with experimental protocols that measure the accuracy and precision with which mice match the ratio of their expected visit durations to the ratio of the incomes obtained from two hoppers, the progress of instrumental and classical conditioning (trials-to-acquisition), the accuracy and precision of interval timing, the effect of relative probability on the choice of a timed departure target, and the accuracy and precision of memory for the times of day at which food is available. The system is compact; it obviates the handling of the mice during testing; it requires negligible amounts of experimenter/technician time; and it delivers clear and extensive results from 3 protocols within a total of 7-9 days after the mice are placed in the test environment. Only a single 24-hour period is required for the completion of first protocol (the matching protocol), which is strong test of temporal and spatial estimation and memory mechanisms. Thus, the system permits the extensive screening of many mice in a short period of time and in limited space. The software is publicly available.
منابع مشابه
Identification of a Neonate with Thalassemia Intermedia Despite Premarital Screening Program in Mazandaran Province (Co-inheritance of Hb Knossos and IVS II-1 G> A Mutations)
Background: Beta thalassemia is a common health problem in Iran especially in Northern provinces. Premarital screening for thalassemia is compulsory in Iran and identification of the carriers is based on primary CBC (Cell Blood Count) and hemoglobin electrophoresis. Silent mutations on β-globin gene have borderline or normal hematological indices that cannot be detected in premarital scree...
متن کاملNootropic Medicinal Plants; Evaluating Potent Formulation By Novelestic High throughput Pharmacological Screening (HTPS) Method
The principle of this method was to screen the pharmacological activity of six prepared polyphyto formulations by using high throughput screening method for their nootropic action. The study was performed in three stages using one, two and three animals, respectively in a group. Test formulations were given p.o daily at the dose of 50 and 100 mg/kg body weight. The test formulations were compar...
متن کاملP15: Hippocampus-Neocortical Communication in Learning
The hippocampus is located in the medial temporal lobe and is a part of the forebrain. It plays a critical role in formation of declared memories. The hippocampus is banana­-shaped and communicates with all parts of neocortex. Reptiles and birds have structures like hippocampus that potentially serve as navigation functions. During the mammalian evolution, the neocortex has a large expansio...
متن کاملEvaluating the Success of the Visual Learners in Vocabulary Learning through Word List versus Sentence Making Approaches
Thisstudy sought to evaluate the learners' achievements with the visual learning style when exposed to the sentence making and word list approaches. On that account, 45 basic level participants who studied at the Iran Language Institute (ILI), Bushehr, took part in this research study. At the outset, the learners were given Barsch learning style inventory (1991) to determine the learners' learn...
متن کاملEvaluating the Success of the Visual Learners in Vocabulary Learning through Word List versus Sentence Making Approaches.
Thisstudy sought to evaluate the learners'''' achievements with the visual learning style when exposed to the sentence making and word list approaches. On that account, 45 basic level participants who studied at the Iran Language Institute (ILI), Bushehr, took part in this research study. At the outset, the learners were given Barsch learning style inventory (1991) to determine the learners''''...
متن کاملChaotic Genetic Algorithm based on Explicit Memory with a new Strategy for Updating and Retrieval of Memory in Dynamic Environments
Many of the problems considered in optimization and learning assume that solutions exist in a dynamic. Hence, algorithms are required that dynamically adapt with the problem’s conditions and search new conditions. Mostly, utilization of information from the past allows to quickly adapting changes after. This is the idea underlining the use of memory in this field, what involves key design issue...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Xin li xue bao. Acta psychologica Sinica
دوره 42 1 شماره
صفحات -
تاریخ انتشار 2010